Also Known As
What is Palmitoylethanolamide?
Palmitoylethanolamide (PEA) is a naturally occurring fatty acid found mainly in egg yolks and mothers milk but is also naturally produced by the body in response to pain. As a supplement has been studied to show neuroprotective anti-inflammatory and analgesic properties.
PEA binds to a receptor in the cell nucleus called peroxisome proliferator-activated receptor alpha (PPARa).This plays an important biological role within cells in response to pain.PEA has a binding affinity for the CB1, CB2 and GPR55 cannabinoid receptors, as well as the TRPV1 capsaicin receptor.
It also reduces the expression of cyclooxygenase-2 (COX-2), inhibits the release of both mast cell mediators, such as histamine and TNF-alpha.All of this means PEA may help in reducing or relieve neuropathic pain and chronic/acute inflammation.If you ever shied away from CBD products due to cost or personal reasons, or they have not been accessible to you, PEA finds the balance you might have been looking for as it works very similarly to CBD for a fraction of the cost!
Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights
Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression
Novel Pharmacologic Approaches to the Prevention and Treatment of Ulcerative Colitis
Focus on Ulcerative Colitis: Stable Gastric Pentadecapeptide BPC 157
The influence of a novel pentadecapeptide, BPC 157, on N G-nitro-L-arginine methyl-ester and L-arginine effects on stomach mucosa integrity and blood pressure
Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression.
BPC157 Rescued NSAID-cytotoxicity via Stabilizing Intestinal Permeability and Enhancing Cytoprotection