BPC-157
Also Known As
BPC-157 | Body Protection Compound |Â Pentadecapeptide | PL10 | PL14736 | Bepecin
What is BPC-157?
BPC-157(body protection compound)is a small molecule peptide that is found naturally in gastric juices/stomach acid.
This peptide protects, heals and restores tissues by the building of new blood vessels and upregulating growth factors such as Vascular Endothelial Growth Factor (VEGF), Epithelial Growth Factor (EGF), Nerve growth factor (NGF)Â and by interacting with the nitric oxide system (NOS), and promotion of new blood vessel formation (Angiogenesis).
These factors lead to an enhanced anabolic healing effect in both the upper and lower GI tract; having an antiulcer effect; and produce a therapeutic effect on all inflammatory bowel diseases, all surprisingly free of side effects. It also enhances growth hormone receptors which can further enhance healing processes systemically, not just in the GIT.
BPC also stimulates granulation tissue via stimulation of growth factors (NGF, EGF) which enhances collagen organisation and enhances wound healing.
Can BPC-157 Work Orally?
BPC as arginine salt (the form used by LVLUP health), almost completely resistant to gastric juices and high temperatures, meaning that unlike other peptides and other forms of BPC157, it can pass through without being denatured or broken down by stomach acid and digestive enzymes; then it can then be absorbed via the gastrointestinal tract to have local healing effects or it can be absorbed into circulation to have systemic healing effects via the growth factors listed above and the mechanisms listed below.
BPC 157 Mechanisms of Action
– Gastro-protective
– Anti-Ulcer
– Nitric Oxide Modulation (NO)
– Anti- Inflammatory
– Cytoprotective
– Upregulates Growth Hormone (GH) Receptors
– Reduces Neuro-inflammation
– Immune Modulating.
– Stimulates Angiogenesis (Blood Vessel Formation)
– Nootropic and Anxiolytic effects (Dopamine and Serotonin receptor modulation)Â
BPC 157 Studies / References:
Butler, R. J., Marchesi, S., Royer, T., & Davis, I. S. (2007). Effective Therapy of Transected Quadriceps Muscle in Rat:Gastric Pentadecapeptide BPC 157. Journal of Orthopaedic Research September, 25(June), 1121–1127. https://doi.org/10.1002/jor
 Brcic, L., Brcic, I., Staresinic, M., Novinscak, T., Sikiric, P., & Seiwerth, S. (2009). Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society, 60 Suppl 7, 191–196.
Cerovecki, T., Bojanic, I., Brcic, L., Radic, B., Vukoja, I., Seiwerth, S., & Sikiric, P. (2010). Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. Journal of Orthopaedic Research, 28(9), 1155–1161. https://doi.org/10.1002/jor.21107
Chang, C. H., Tsai, W. C., Hsu, Y. H., & Pang, J. H. S. (2014). Pentadecapeptide bpc 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules, 19(11), 19066–19077. https://doi.org/10.3390/molecules191119066Â
Chang, C. H., Tsai, W. C., Lin, M. S., Hsu, Y. H., & Su Pang, J. H. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 110(3), 774–780. https://doi.org/10.1152/japplphysiol.00945.2010
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Gjurasin, M., Miklic, P., Zupancic, B., Perovic, D., Zarkovic, K., Brcic, L., Sikiric, P. (2010). Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury. Regulatory Peptides, 160(1–3), 33–41. https://doi.org/10.1016/j.regpep.2009.11.005
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Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 377(2), 153–159. https://doi.org/10.1007/s00441-019-03016-8
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Perovic, D., Kolenc, D., Bilic, V., Somun, N., Drmic, D., Elabjer, E., … Sikiric, P. (2019). Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. Journal of Orthopaedic Surgery and Research, 14(1), 1–12. https://doi.org/10.1186/s13018-019-1242-6
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Pevec, D., Novinscak, T., Brcic, L., Sipos, K., Jukic, I., Staresinic, M., … Sikiric, P. (2010). Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Medical Science Monitor, 16(3), 81–88. https://pubmed.ncbi.nlm.nih.gov/20190676/
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Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., … Kolega, Z. (1997). BPC 157’s effect on Healing. Journal of Physiology Paris, 91(3–5), 173–178. https://doi.org/10.1016/S0928-4257(97)89480-6
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Sever, A. Z., Sever, M., Vidovic, T., Lojo, N., Kolenc, D., Vuletic, L. B., … Sikiric, P. (2019). Stable gastric pentadecapeptide BPC 157 in the therapy of the rats with bile duct ligation. European Journal of Pharmacology, 847(January), 130–142. https://doi.org/10.1016/j.ejphar.2019.01.030
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Sikiric, P. (1999). The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology, 7(1), 1–14. https://doi.org/10.1007/s10787-999-0022-z
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Sikiric, P., Petek, M., Rucman, R., Seiwerth, S., Grabarevic, Z., Rotkvic, I., … Karakas, I. (1993). A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC. Journal of Physiology – Paris, 87(5), 313–327. https://doi.org/10.1016/0928-4257(93)90038-U
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Sikiric, P., Seiwerth, S., Rucman, R., Kolenc, D., Vuletic, L. B., Drmic, D., Grgic, T., Strbe, S., Zukanovic, G., Crvenkovic, D., Madzarac, G., Rukavina, I., Sucic, M., Baric, M., Starcevic, N., Krstonijevic, Z., Bencic, M. L., Filipcic, I., Rokotov, D. S., & Vlainic, J. (2016). Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Current neuropharmacology, 14(8), 857–865. https://doi.org/10.2174/1570159×13666160502153022
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Staresinic, M., Sebecic, B., Patrlj, L., Jadrijevic, S., Suknaic, S., Perovic, D., … Sikiric, P. (2003). Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. Journal of Orthopaedic Research, 21(6), 976–983. https://doi.org/10.1016/S0736-0266(03)00110-4
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