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Synergistic enzyme and botanical complex supporting histamine metabolism, mast cell stability, and daily resilience for sensitive individuals.
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      Hista-Resist

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      Targeted Enzyme and Botanical Support for Histamine Balance
      DAO Enzyme Support
      Mast Cell Stabilization
      Botanical Polyphenol Complex
      Digestive Resilience Formula
      In Stock
      $89.99 USD
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      30 Servings
      90 Capsules
      Synergistic enzyme and botanical complex supporting histamine metabolism, mast cell stability, and daily resilience for sensitive individuals.

      Targeted Enzyme and Botanical Support for Histamine Balance

      LVLUP Health Hista-Resist is designed for individuals seeking advanced nutritional support for balanced histamine responses. This comprehensive formula delivers 20,000 HDU of DAO2 enzyme to help break down dietary histamine before absorption. Botanical polyphenols – including Quercetin, EMIQ, Luteolin, Bromelain, and Baicalin – work in concert to help maintain mast cell stability and moderate immune signaling. Essential cofactors Vitamin C, Copper, and B2 further support enzymatic pathways crucial for histamine clearance. Backed by transparent dosing and rigorous manufacturing standards, Hista-Resist offers a multi-faceted approach to everyday histamine management.

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      20000 mg
      DAO2
      DAO2 is a highly active source of diamine oxidase enzyme extracted from pig kidneys. It supports the breakdown of food-derived histamine within the digestive tract - particularly useful when natural enzyme levels are low due to genetic or environmental factors.
      21 mg
      Vitamin B2
      Vitamin B2, also known as riboflavin, plays a crucial role in converting calories into energy and maintaining healthy cells. It's commonly found in foods like dairy, eggs, lean meats, and leafy vegetables. As part of the B vitamin family, it's often included in supplements for energy support, brain health, and overall wellness.
      90 mg
      Vitamin C
      Vitamin C, also known as ascorbic acid, is a water-soluble vitamin celebrated for its role in immune support and skin health. Its applications range from cellular protection to aiding collagen synthesis and enhancing iron absorption. This versatility makes it a staple in many supplement formulas.
      90 mg
      Luteolin
      Luteolin is a natural flavonoid found in plants like celery, parsley, and chamomile. Known for its potential benefits on brain, gut, and immune health, it's often used in supplements aimed at calming the digestive system and balancing histamine levels.
      120 mg
      Rutin
      Rutin is a plant flavonoid found in foods like buckwheat, apples, and citrus peels. It's valued for its role in supporting heart, brain, and vascular health. Known for aiding digestion and regulating histamine response, rutin is a versatile supplement component.
      150 mg
      Baical Skullcap
      Baical skullcap is a yellow-rooted herb used in East Asian wellness practices. Its main compound, baicalin, is valued for supporting immune health, brain function, and balancing histamine levels.
      180 mg
      Pineapple Enzyme
      Bromelain, found in pineapple stems, is known for its protein-digesting abilities. It’s often used to aid digestion, promote muscle recovery, and support your immune system in managing stress. This enzyme also acts as a natural anti-inflammatory and anti-histamine, making it useful for those concerned about histamine reactions and physical discomfort.
      210 mg
      PEA
      Palmitoylethanolamide, or PEA, is a naturally occurring fatty molecule in your body. It increases during times of stress or discomfort. Though found in foods like peanuts and egg yolks, these sources often fall short when the body's demands are high. As a supplement, PEA is popular for supporting nerve comfort and helping maintain balance during physical or emotional stress.
      210 mg
      Quercetin Combo
      Quercetin Combination blends quercetin with nutrients like bromelain, vitamin C, or resveratrol to improve absorption and amplify antioxidant effects. These formulas often target immune support, inflammation, and overall wellness.
      300 mg
      Black Seed Oil Extract
      Black Seed Oil Extract, derived from the seeds of Nigella sativa, has historical roots in traditional medicine across Asia and the Middle East. Known for its potential benefits in supporting gut health, immune function, and allergy response, it's recognized today for its active component, thymoquinone, which is being studied for its role in reducing oxidative stress and modulating immune responses.
      12 mg
      Copper Citrate
      Cupric citrate, commonly known as copper citrate, is a highly absorbable form of copper found in many supplements. This essential mineral plays a key role in enzyme activity and overall cellular health. Its benefits range from supporting energy production and DNA synthesis to aiding in antioxidant defense and histamine metabolism.
      3
      Capsules
      Serving Size
      90
      Capsules
      Package Contents

        Hista-Resist

        Supplies 20,000 HDU DAO2 enzyme per serving to facilitate histamine breakdown
        Combines polyphenols like Quercetin, EMIQ, and Luteolin to support immune balance
        Delivers Vitamin C, B2, and Copper as key metabolic cofactors for enzyme function
        Contains Coleus forskohlii to help sustain healthy digestive processes and resilience
        Broad-spectrum formulation addresses multiple stages of histamine metabolism in the gut and cells
        Standardized botanical extracts provide consistency of actives in every batch
        Transparent ingredient labeling with clinically relevant dosages clearly listed on each bottle
        Manufactured under strict GMP protocols with independent third-party testing
        DAO Enzyme Support

        Histamine breakdown begins at the digestive level. Hista-Resist supplies 20,000 HDU of DAO2 enzyme from porcine kidney extract per serving – a level calibrated to act efficiently within the gastrointestinal tract. By supporting dietary histamine degradation before it enters circulation, this mechanism is especially valuable for those sensitive to high-histamine foods. Reliable dosing ensures consistent activity meal after meal.

        Mast Cell Stabilization

        Plant-derived polyphenols including Quercetin (with EMIQ), Luteolin, Baicalin (from Skullcap), Bromelain, and PEA work synergistically to support normal mast cell function. These nutrients are studied for their ability to help maintain cellular stability under stressors such as food or environmental triggers. This combination aims for a steady baseline rather than broad immune suppression.

        Metabolic Cofactor Synergy

        Vitamin C (ascorbic acid), Copper (as cupric citrate), and Vitamin B2 (riboflavin) play pivotal roles in activating enzymes responsible for breaking down both dietary and circulating histamine. By providing these cofactors alongside DAO2, Hista-Resist supports the body’s metabolic clearance systems over time – helping maintain balance at the cellular level.

        Digestive Resilience

        Coleus forskohlii extract is included to promote healthy gastric acid production – an important factor in protein digestion. Efficient digestion reduces exposure to undigested food components that might otherwise challenge immune tolerance. This botanical complements the formula’s focus on maintaining gut integrity as part of daily wellness.

        Polyphenol-Rich Antioxidants

        Rutin and Black Seed Oil Extract offer a rich source of antioxidants while contributing additional polyphenols with immune-modulating potential. Their presence helps strengthen cellular defenses against oxidative stress that may coincide with heightened histamine activity.

        Bromelain-Assisted Absorption

        Bromelain’s natural proteolytic activity supports optimal digestion of proteins and enhances bioavailability of key phytonutrients within the blend. This dual role ensures that both digestive comfort and nutrient absorption are prioritized with each dose.

        Non-Sedating Daily Use

        Unlike conventional antihistamines that may cause drowsiness or cognitive dulling, Hista-Resist utilizes natural pathways focused on enzymatic breakdown rather than blocking receptors. Its comprehensive design supports alertness and energy throughout daily use.

        Quality And Testing Assurance

        Every batch of Hista-Resist is manufactured under GMP standards and independently tested for purity and potency of active ingredients including DAO2 enzyme activity. Full label transparency ensures you know exactly what you are getting – batch after batch.

          DAO Enzyme Support

          Histamine breakdown begins at the digestive level. Hista-Resist supplies 20,000 HDU of DAO2 enzyme from porcine kidney extract per serving – a level calibrated to act efficiently within the gastrointestinal tract. By supporting dietary histamine degradation before it enters circulation, this mechanism is especially valuable for those sensitive to high-histamine foods. Reliable dosing ensures consistent activity meal after meal.

          Mast Cell Stabilization

          Plant-derived polyphenols including Quercetin (with EMIQ), Luteolin, Baicalin (from Skullcap), Bromelain, and PEA work synergistically to support normal mast cell function. These nutrients are studied for their ability to help maintain cellular stability under stressors such as food or environmental triggers. This combination aims for a steady baseline rather than broad immune suppression.

          Metabolic Cofactor Synergy

          Vitamin C (ascorbic acid), Copper (as cupric citrate), and Vitamin B2 (riboflavin) play pivotal roles in activating enzymes responsible for breaking down both dietary and circulating histamine. By providing these cofactors alongside DAO2, Hista-Resist supports the body’s metabolic clearance systems over time – helping maintain balance at the cellular level.

          Digestive Resilience

          Coleus forskohlii extract is included to promote healthy gastric acid production – an important factor in protein digestion. Efficient digestion reduces exposure to undigested food components that might otherwise challenge immune tolerance. This botanical complements the formula’s focus on maintaining gut integrity as part of daily wellness.

          Polyphenol-Rich Antioxidants

          Rutin and Black Seed Oil Extract offer a rich source of antioxidants while contributing additional polyphenols with immune-modulating potential. Their presence helps strengthen cellular defenses against oxidative stress that may coincide with heightened histamine activity.

          Bromelain-Assisted Absorption

          Bromelain’s natural proteolytic activity supports optimal digestion of proteins and enhances bioavailability of key phytonutrients within the blend. This dual role ensures that both digestive comfort and nutrient absorption are prioritized with each dose.

          Non-Sedating Daily Use

          Unlike conventional antihistamines that may cause drowsiness or cognitive dulling, Hista-Resist utilizes natural pathways focused on enzymatic breakdown rather than blocking receptors. Its comprehensive design supports alertness and energy throughout daily use.

          Quality And Testing Assurance

          Every batch of Hista-Resist is manufactured under GMP standards and independently tested for purity and potency of active ingredients including DAO2 enzyme activity. Full label transparency ensures you know exactly what you are getting – batch after batch.

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          How It Works

          Immediate Histamine Breakdown

          Upon ingestion before meals, the DAO2 enzyme acts within the digestive tract by breaking down dietary histamine molecules before they can be absorbed systemically. This first-line mechanism helps limit how much intact histamine reaches circulation from food sources.

          What to Know

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          FAQ

          How quickly does Hista-Resist work?
          The DAO2 enzyme begins acting soon after ingestion; many users find effects starting within their first meal containing higher-histamine foods. Polyphenol-driven mast cell support typically builds gradually over days or weeks when used consistently.
          Is Hista-Resist suitable for long-term daily use?
          Yes; each ingredient has an established safety profile when used at recommended amounts by adults without ingredient-specific allergies or sensitivities. The formula does not cause sedation or dependence.
          Can I combine this product with prescribed antihistamines?
          There are no known direct interactions between this formula’s natural ingredients and prescription medications; however, consult your healthcare provider before combining supplements with medication due to individual considerations.
          Will this help all forms of food intolerance?
          Hista-Resist is formulated specifically around mechanisms involved in dietary histamine metabolism rather than intolerances related to gluten or dairy proteins such as lactose intolerance.
          Are there any side effects?
          Side effects are uncommon but may include mild digestive discomfort initially; avoid use if allergic to pork-derived enzymes or specific plant extracts included in this product.
          Who should not take Hista-Resist?
          Individuals allergic to porcine products or any other listed ingredient should not use this product; pregnant or breastfeeding women should consult their medical professional prior to supplementation.
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