Tesofensine

Tesofensine with L-Baiba and GBB = Intense Sauna and Exercise, in a Pill! 

*Please use cautiously for first time users to assess tolerance, and read instructions and cautions further down. *May cause excessive sweating and salivation that subsides in a few hours. *Do Not take before bed, please be aware first time use may be unpleasant. 

Tesofensine is a research compound designed to support Weight Management by influencing neurotransmitter levels that impact appetite and metabolism. 

Originally developed for neurological conditions, Tesofensine has shown remarkable efficacy in reducing hunger while simultaneously boosting energy expenditure and mitochondrial uncoupling (heat generation) making it a valuable tool for those aiming to achieve healthy weight loss. 

By targeting key neurotransmitters like dopamine, serotonin, and noradrenaline, it helps manage cravings and promotes a feeling of fullness, supporting sustained, healthy weight loss when combined with a balanced diet and exercise. 

To work in synergy with this amazing compound we've added:
 - L-BAIBA and GBB to potentiate the actions:

• Dose: Start with 125 mcg every other day.
• Purpose: Allow the body to adjust to tesofensine’s effects, particularly its impact on dopamine, norepinephrine, and serotonin reuptake.
• Effects Noticed: Appetite suppression, slight mood elevation, and increased energy.

• Dose: Increase to 125 mcg daily, taken in the morning with or without food.
• Reason for Timing: Early dosing minimises potential insomnia caused by heightened catecholamine activity.
• Expected Effects:
  • Significant appetite suppression and caloric intake reduction.
  • Improved focus and energy throughout the day.
  • Mild mood-enhancing effects due to dopamine regulation.

• Dose: Optionally, increase to 250 mcg every other day for those who experience tolerance or diminishing effects. Maintain this protocol for a maximum of 4 weeks.
• Purpose: Overcome metabolic plateaus or appetite creep without overloading catecholamine systems.

• Option 1: Resume 125 mcg daily for another 4–6 weeks if the body handles it well.
• Option 2: Introduce a 4-week "off-cycle" to reset sensitivity before resuming

⚠️ Supplements to Use Cautiously/Avoid⚠️

1. Methylene Blue:
   • Reason: Enhances serotonin and may elevate dopamine. Combined with Tesofensine, this can increase the risk of serotonin syndrome (symptoms include confusion, rapid heart rate, sweating, and tremors).
   • Suggestion: Use at very low doses (e.g., 0.5–1 mg/kg) and monitor for signs of overstimulation.
2. Psilocybin and Other Psychedelics:
   • Reason: Psychedelics also interact with serotonin receptors. When combined with Tesofensine, the risk of serotonin toxicity increases, and the psychological effects may become unpredictable.
   • Suggestion: Avoid simultaneous use. If experimenting, allow a significant washout period between substances.
3. High-Dose Caffeine or Stimulants (e.g., DMAA, Ephedrine):
   • Reason: Amplifies catecholamine activity, increasing the likelihood of jitteriness, high blood pressure, or heart palpitations.
   • Suggestion: Limit caffeine intake to moderate levels (e.g., ≤200 mg daily) and avoid stacking with strong stimulants.
4. 5-HTP or Tryptophan:
   • Reason: Tesofensine already boosts serotonin levels. Adding serotonin precursors can heighten the risk of serotonin syndrome.
   • Suggestion: Avoid concurrent use or use only under supervision.
5. High-Dose Tyrosine or Dopamine Boosters:
   • Reason: Tesofensine increases dopamine availability; adding precursors like L-Tyrosine or Mucuna Pruriens (L-DOPA) may exacerbate overstimulation or irritability.
   • Suggestion: If used, keep doses low (e.g., <500 mg/day).

⚠️ Medications to Avoid or Use With Caution

1. SSRIs (e.g., Sertraline, Fluoxetine, Escitalopram):
   • Reason: Both Tesofensine and SSRIs increase serotonin levels. Combined, they greatly elevate the risk of serotonin syndrome.
   • Suggestion: Do not combine unless under strict medical supervision.
2. MAO Inhibitors (e.g., Selegiline, Phenelzine):
   • Reason: MAO inhibitors prevent the breakdown of catecholamines and serotonin, compounding Tesofensine’s effects. This can result in dangerously high catecholamine levels or hypertensive crises.
   • Suggestion: Absolute contraindication.
3. Tricyclic Antidepressants (e.g., Amitriptyline, Nortriptyline):
   • Reason: These also inhibit serotonin and norepinephrine reuptake, compounding Tesofensine’s effects and increasing cardiovascular risk.
   • Suggestion: Avoid combination.
4. SNRIs (e.g., Duloxetine, Venlafaxine):
   • Reason: Overlapping mechanisms (norepinephrine and serotonin reuptake inhibition) can lead to overstimulation and serotonin syndrome.
   • Suggestion: Avoid concurrent use.
5. Antihypertensives (e.g., Beta Blockers, Clonidine):
   • Reason: Tesofensine may elevate blood pressure, potentially counteracting these medications or causing fluctuations in blood pressure control.
   • Suggestion: Monitor blood pressure closely if using antihypertensives.
6. Other Appetite Suppressants (e.g., Phentermine, Bupropion/Naltrexone):
   • Reason: Adding Tesofensine to other appetite suppressants can lead to excessive catecholamine stimulation, increasing risks of tachycardia, anxiety, and mood disturbances.
   • Suggestion: Use one agent at a time.
7. Recreational Drugs (e.g., MDMA, Cocaine):
   • Reason: Both substances heavily impact dopamine, serotonin, and norepinephrine systems, compounding Tesofensine’s effects and significantly increasing cardiovascular and neurological risks.
   • Suggestion: Strictly avoid.